Hercules and Amadeus. Have they met up in this timeline? If so, they're a factor that has to be considered.

T'Challa and Storm are another serious threat.

Magneto, who's status is so ever changing it's largely up to you.

The geniuses. You've got to nail them down. Maya Hansen, Hank McCoy, Alyssa Moy, the Leader, the Mandarin, Sinister, the High Evolutionary. Just know where they are in your universe because they're all game changers.